Meanwhile, the global burden of dengue has been increasing over the past 50 years, with an annual incidence estimate of about 350 million infections, and about half of the world’s population in endemic areas is at risk. Globally, malaria was estimated to affect 229 million people and cause 409,000 deaths in 2019 across 87 countries. Malaria and dengue are major mosquito-borne diseases in terms of morbidity and mortality in tropical and subtropical countries.
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